Trpv5 Gene Summary [Mouse]
Enables calcium channel activity. Involved in calcium ion homeostasis; calcium ion transmembrane transport; and regulation of urine volume. Located in apical plasma membrane. Part of calcium channel complex. Is expressed in central nervous system; extraembryonic component; metanephros; placenta; and sensory organ. Orthologous to human TRPV5 (transient receptor potential cation channel subfamily V member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trpv5 |
| Official Name | transient receptor potential cation channel, subfamily V, member 5 [Source:MGI Symbol;Acc:MGI:2429764] |
| Ensembl ID | ENSMUSG00000036899 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily V, member 5 |
| Synonyms | CAT2, D630033B11, Ecac, ECAC1, OTRPC3, transient receptor potential cation channel subfamily V member 5, transient receptor potential cation channel, subfamily V, member 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trpv5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- Ion transport protein
- calcium channel
- Ankyrin repeats (3 copies)
- transient-receptor-potential calcium channel protein
- protein binding
- ion channel
- Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
- Ankyrin repeat
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Trpv5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- androgenic alopecia
- diabetic nephropathy
- hypervitaminosis D
- hypercalciuria
- rickets
- phosphaturia
- cancer
- hypocalcemia
- hypocalciuria
role in cell
- quantity
- number
- transport in
- resorption by
- area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- cellular membrane
- vesicles
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trpv5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of urine volume
- protein homotetramerization
- calcium ion homeostasis
- calcium ion transport
- calcium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- metal ion binding
- calcium channel activity