Tafa4 Gene Summary [Mouse]
Enables receptor ligand activity. Involved in several processes, including macrophage chemotaxis; phagocytosis; and superoxide anion generation. Acts upstream of or within regulation of membrane potential and regulation of sensory perception of pain. Located in extracellular space. Is active in glutamatergic synapse and synaptic vesicle membrane. Is expressed in central nervous system; dorsal root ganglion; inner ear; and tooth. Orthologous to human TAFA4 (TAFA chemokine like family member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tafa4 |
| Official Name | TAFA chemokine like family member 4 [Source:MGI Symbol;Acc:MGI:2444563] |
| Ensembl ID | ENSMUSG00000046500 |
| Bio databases IDs | |
| Aliases | TAFA chemokine like family member 4 |
| Synonyms | C130034I18Rik, FAM19A4, Fam19a4 Tafa-4, LOC687122, TAFA chemokine like family member 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tafa4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor agonist activity
- protein binding
- TAFA family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- fibrosis
- myelodysplastic syndrome
- vertigo
- refractive error
- pediatric inflammatory bowel disease
- aldosterone producing adrenocortical adenoma
role in cell
- expression in
- phagocytosis by
- chemotaxis
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- synaptic vesicle membrane
- glutaminergic synapse
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tafa4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of membrane potential
- macrophage chemotaxis
- signal transduction
- phagocytosis
- regulation of receptor activity
- superoxide anion generation
- regulation of sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor agonist activity