Zer1 Gene Summary [Mouse]
Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in central nervous system and retina. Orthologous to human ZER1 (zyg-11 related cell cycle regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zer1 |
| Official Name | zyg-11 related, cell cycle regulator [Source:MGI Symbol;Acc:MGI:2442511] |
| Ensembl ID | ENSMUSG00000039686 |
| Bio databases IDs | |
| Aliases | zyg-11 related, cell cycle regulator |
| Synonyms | C230075L19Rik, C9orf60, RGD1310284, ZYG, ZYG11BL, zyg-11 related cell cycle regulator, zyg-11 related, cell cycle regulator |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zer1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zer1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- misfolded or incompletely synthesized protein catabolic process
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- Cul2-RING ubiquitin ligase complex