Cox17 Gene Summary [Mouse]
Enables copper ion binding activity and enzyme activator activity. Involved in mitochondrial cytochrome c oxidase assembly. Is active in mitochondrion. Is expressed in several structures, including genitourinary system; liver; lung; small intestine; and spleen. Orthologous to human COX17 (cytochrome c oxidase copper chaperone COX17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox17 |
| Official Name | cytochrome c oxidase assembly protein 17, copper chaperone [Source:MGI Symbol;Acc:MGI:1333806] |
| Ensembl ID | ENSMUSG00000046516 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase assembly protein 17, copper chaperone |
| Synonyms | cytochrome c oxidase assembly protein 17, copper chaperone, cytochrome c oxidase copper chaperone COX17, LOC100043715 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cox17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion binding
- copper chaperone
- enzyme
- protein binding
- enzyme activator activity
- Cytochrome C oxidase copper chaperone (COX17)
Pathways
Biological processes and signaling networks where the Cox17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
regulates
- heavy metal
- Cu2+
- cytochrome-c oxidase
role in cell
- proliferation
- density
- growth
- fragmentation
- fragmentation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial intermembrane space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cox17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- copper ion transport
- mitochondrial respiratory chain complex IV assembly
- generation of precursor metabolites and energy
- positive regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- enzyme activator activity
- copper chaperone activity