Chtf8 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in positive regulation of DNA-directed DNA polymerase activity. Predicted to be located in nucleoplasm. Predicted to be part of Ctf18 RFC-like complex. Orthologous to several human genes including CHTF8 (chromosome transmission fidelity factor 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chtf8 |
| Official Name | CTF8, chromosome transmission fidelity factor 8 [Source:MGI Symbol;Acc:MGI:2443370] |
| Ensembl ID | ENSMUSG00000046691 |
| Bio databases IDs | |
| Aliases | CTF8, chromosome transmission fidelity factor 8 |
| Synonyms | 5830457O10Rik, chromosome transmission fidelity factor 8, CTF8, CTF8, chromosome transmission fidelity factor 8, DERPC, LOC690176, RGD1306894 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chtf8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA dependent ATP dependent DNA helicase
- Ctf8
- DNA clamp loader
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chtf8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA duplex unwinding
- DNA replication
- mitotic sister chromatid cohesion
- positive regulation of DNA-directed DNA polymerase activity
Cellular Component
Where in the cell the gene product is active
- Ctf18 RFC-like complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- DNA clamp loader activity
- single-stranded DNA-dependent ATP-dependent DNA helicase activity