Rad50 Gene Summary [Mouse]
Predicted to enable several functions, including ATP hydrolysis activity; DNA binding activity; and protein serine/threonine kinase activator activity. Predicted to contribute to 3'-5' exonuclease activity; DNA helicase activity; and single-stranded DNA endodeoxyribonuclease activity. Acts upstream of or within chromosome organization involved in meiotic cell cycle and regulation of mitotic cell cycle. Located in pronucleus. Part of Mre11 complex. Is expressed in several structures, including aorta; genitourinary system; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in transitional cell carcinoma. Orthologous to human RAD50 (RAD50 double strand break repair protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad50 |
| Official Name | RAD50 double strand break repair protein [Source:MGI Symbol;Acc:MGI:109292] |
| Ensembl ID | ENSMUSG00000020380 |
| Bio databases IDs | |
| Aliases | RAD50 double strand break repair protein |
| Synonyms | hRad50, Mrell, NBSLD, RAD502, RAD50 double strand break repair protein, Rad50l |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad50 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exonuclease
- walker type B motif
- Synaptonemal complex protein 1 (SCP-1)
- protein binding activity, bridging
- helix-rich Mycoplasma protein
- leucine zipper domain
- enzyme
- identical protein binding
- ATPase
- DNA helicase
- ERM binding domain
- chromosome segregation protein SMC, common bacterial type
- Mitotic checkpoint protein
- Crescentin protein
- SbcC/RAD50-like, Walker B motif
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- rad50
- Myosin tail
- protein binding
- Rad50 zinc hook motif
- single-stranded DNA specific endodeoxyribonuclease
- DNA binding
- AAA domain
- protein kinase activator
- RecF/RecN/SMC N terminal domain
- binding protein
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the Rad50 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- ATM Signaling
- DNA Double-Strand Break Repair by Homologous Recombination
- DNA Double-Strand Break Repair by Non-Homologous End Joining
- Hereditary Breast Cancer Signaling
- Molecular Mechanisms of Cancer
- Role of BRCA1 in DNA Damage Response
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Telomere Extension by Telomerase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- cancer
- neoplasia
- breast cancer
- breast carcinoma
- epithelial cancer
- epithelial neoplasia
- liver neoplasia
- tumorigenesis
- hereditary cancer-predisposing syndrome
role in cell
- apoptosis
- cell death
- activation in
- survival
- phosphorylation in
- proliferation
- formation
- damage in
- number
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- anaphase bridge
- intracellular space
- perinuclear region
- midbody remnant
- chromosome
- nucleoplasm
- nucleoli
- pronucleus
- DNA replication foci
- PML nuclear bodies
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad50 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA double-strand break processing
- reciprocal meiotic recombination
- double-strand break repair via homologous recombination
- DNA recombination
- regulation of mitotic recombination
- telomere maintenance via telomerase
- telomere maintenance
- telomere maintenance via recombination
- response to DNA damage stimulus
- chromosome organization involved in meiosis
- double-strand break repair
- positive regulation of protein autophosphorylation
- DNA duplex unwinding
- telomeric 3' overhang formation
- positive regulation of kinase activity
- reciprocal DNA recombination
- positive regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- site of double-strand break
- membrane
- BRCA1-C complex
- Mre11 complex
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- identical protein binding
- protein serine/threonine kinase activator activity
- double-stranded telomeric DNA binding
- single-stranded telomeric DNA binding
- single-stranded DNA specific endodeoxyribonuclease activity
- 3'-5' exonuclease activity
- ATP binding
- DNA binding
- DNA helicase activity
- protein binding
- G-quadruplex DNA binding
- metal ion binding
- protein binding, bridging