Paxx Gene Summary [Mouse]
Predicted to enable DNA polymerase binding activity; molecular adaptor activity; and protein homodimerization activity. Involved in double-strand break repair via nonhomologous end joining. Predicted to be located in nucleoplasm. Predicted to be part of Ku70:Ku80 complex and nonhomologous end joining complex. Predicted to be active in nucleus and site of double-strand break. Is expressed in brain; cortical plate; lung; spleen; and thymus. Orthologous to human PAXX (PAXX non-homologous end joining factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Paxx |
| Official Name | non-homologous end joining factor [Source:MGI Symbol;Acc:MGI:2442831] |
| Ensembl ID | ENSMUSG00000047617 |
| Bio databases IDs | |
| Aliases | non-homologous end joining factor |
| Synonyms | BC029214, C9orf142, D930050G13Rik, non-homologous end joining factor, PAXX non-homologous end joining factor, PAXX, non-homologous end joining factor, RGD1306215, XLS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Paxx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PAXX, PAralog of XRCC4 and XLF, also called C9orf142
- enzyme binding
- protein homodimerization
- protein binding
- N-terminal head domain found in the XRCC4 superfamily of proteins
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- organismal death
- chromosomal instability
- HER2 negative hormone receptor negative breast cancer
role in cell
- expression in
- growth
- invasiveness
- DNA damage response
- S phase
- G1 phase
- migratory capacity
- abemaciclib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Paxx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to DNA damage stimulus
- double-strand break repair via nonhomologous end joining
Cellular Component
Where in the cell the gene product is active
- nucleus
- nonhomologous end joining complex
- site of double-strand break
- cytoplasm
- Ku70:Ku80 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA polymerase binding
- protein binding
- protein homodimerization activity
- binding, bridging