Ccdc88b Gene Summary [Mouse]
Predicted to enable dynein light intermediate chain binding activity and microtubule binding activity. Involved in defense response to protozoan; positive regulation of T cell proliferation; and positive regulation of cytokine production. Located in membrane. Orthologous to human CCDC88B (coiled-coil domain containing 88B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccdc88b |
| Official Name | coiled-coil domain containing 88B [Source:MGI Symbol;Acc:MGI:1925567] |
| Ensembl ID | ENSMUSG00000047810 |
| Bio databases IDs | |
| Aliases | coiled-coil domain containing 88B |
| Synonyms | 2610041P08Rik, BRLZ, CCDC88, coiled-coil domain containing 88B, gipie, HKRP3, RGD1311475 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccdc88b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Hook domain-containing proteins superfamily
- Crescentin protein
- Domain of unknown function (DUF4686)
- chromosome segregation protein SMC, common bacterial type
- chromosome segregation protein SMC, primarily archaeal type
- Ciliary protein causing Leber congenital amaurosis disease
- HOOK domain
- Myosin tail
- enzyme
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary biliary cirrhosis
- epithelial cancer
- Crohn disease
- epithelial basal cell carcinoma
- psoriasis
- eczema
- insulin-dependent diabetes mellitus
- neuroinflammation
- autoimmune disease
- primary sclerosing cholangitis
role in cell
- expression in
- apoptosis
- phosphorylation in
- proliferation
- production in
- binding in
- maturation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- Plasma Membrane
- centrosome
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccdc88b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell activation
- cytoskeleton-dependent intracellular transport
- cytoplasmic microtubule organization
- positive regulation of T cell proliferation
- positive regulation of cytokine production
- defense response to protozoan
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- membrane
- cytosol
- endoplasmic reticulum
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- dynein light intermediate chain binding
- microtubule binding