Bex2 Gene Summary [Mouse]
Enables molecular function inhibitor activity. Involved in negative regulation of protein ubiquitination. Predicted to be part of transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including gut; lung; nervous system; sensory organ; and skeletal musculature. Orthologous to several human genes including BEX1 (brain expressed X-linked 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bex2 |
| Official Name | brain expressed X-linked 2 [Source:MGI Symbol;Acc:MGI:1338017] |
| Ensembl ID | ENSMUSG00000042750 |
| Bio databases IDs | |
| Aliases | brain expressed X-linked 2 |
| Synonyms | BEX2, brain expressed X-linked 1, brain expressed X-linked 2, HBEX2, HGR74-h, REX-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bex2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Brain expressed X-linked like family
- protein binding activity, bridging
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tuberculosis
- breast carcinoma
- metastatic colorectal cancer
- Parkinson disease
- thyroid carcinoma
- epithelial thyroid cancer
regulates
- DNA promoter
- DNA endogenous promoter
- VEGF
- RNA polymerase II
role in cell
- production in
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bex2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell differentiation
- nervous system development
- negative regulation of protein ubiquitination
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- receptor binding