Firre Gene Summary [Mouse]
This gene produces a long non-coding RNA that is localized to the nuclear matrix. This RNA contains repeated sequence motifs that mediate interactions with heterogeneous nuclear ribonucleoprotein U (hnRNPU). Loss of expression of this locus disrupts three-dimensional chromosomal associations. Alternative splicing results in multiple splice variants, though the full length nature of these variants is not known. [provided by RefSeq, Mar 2015]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | Firre |
| Official Name | functional intergenic repeating RNA element [Source:MGI Symbol;Acc:MGI:2147989] |
| Ensembl ID | ENSMUSG00000085396 |
| Bio databases IDs | |
| Aliases | functional intergenic repeating RNA element |
| Synonyms | 5830467J12Rik, 6720401G13Rik, firre intergenic repeating RNA element, functional intergenic repeating RNA element, LINC01200, LOC100047264, LOC286467 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Firre often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- metastasis
- obesity
- lung adenocarcinoma
- lung adenocarcinoma formation
- osteosarcoma
- osteosarcomagenesis
- organismal death
role in cell
- expression in
- migration
- invasion by
- proliferation
- binding in
- M1 polarization
- frequency
- organization
- autophagy in
- M2 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- autosome
- nucleoplasm
- Barr body
- X chromosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Firre gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- Barr body
- X chromosome
- autosome
Molecular Function
What the gene product does at the molecular level
- protein binding