Lmod1 Gene Summary [Mouse]
Predicted to enable tropomyosin binding activity. Predicted to be involved in actin cytoskeleton organization; muscle contraction; and positive regulation of actin filament polymerization. Predicted to be located in actin filament; cytosol; and sarcomere. Predicted to be active in striated muscle thin filament. Is expressed in several structures, including aorta; genitourinary system; gut; inner ear; and musculature. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to human LMOD1 (leiomodin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmod1 |
| Official Name | leiomodin 1 (smooth muscle) [Source:MGI Symbol;Acc:MGI:2135671] |
| Ensembl ID | ENSMUSG00000048096 |
| Bio databases IDs | |
| Aliases | leiomodin 1 (smooth muscle) |
| Synonyms | 1D, 9530015K06Rik, D1, leiomodin 1, leiomodin 1 (smooth muscle), MMIHS3, SM-LMOD |
| Species | Mouse, Mus musculus |
| Orthologies |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- Huntington disease
- colorectal cancer
- neuroticism
- megacystis-microcolon-intestinal hypoperistalsis syndrome type 3
- coronary artery disease
- endometrial cancer
- visceral myopathy type 1
- hydronephrosis
- tracheoesophageal fistula
regulates
- actin
- LMOD1
role in cell
- expression in
- formation in
- activity
- formation
- polymerization
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- cellular membrane
- actin filaments
- sarcomere
- cytosol
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lmod1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myofibril assembly
- pointed-end actin filament capping
- muscle contraction
- actin nucleation
- positive regulation of actin filament polymerization
- actin filament organization
Cellular Component
Where in the cell the gene product is active
- striated muscle thin filament
- cytoskeleton
- membrane
- cytosol
- actin filament
- sarcomere
- myofibril
Molecular Function
What the gene product does at the molecular level
- actin binding
- tropomyosin binding