Nupl2 Gene Summary [Mouse]
Predicted to enable nuclear export signal receptor activity. Predicted to be involved in nucleocytoplasmic transport. Located in photoreceptor outer segment. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human NUP42 (nucleoporin 42). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nupl2 |
| Official Name | nucleoporin like 2 [Source:MGI Symbol;Acc:MGI:2387631] |
| Ensembl ID | ENSMUSG00000048439 |
| Bio databases IDs | |
| Aliases | nucleoporin like 2 |
| Synonyms | CG1, hCG1, NLP-1, nucleoporin 42, NUPL2, RGD1560934, UIP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nupl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FG repeat
- zinc finger
- CCCH-type zinc finger
- coiled-coil domain
- protein binding
- zinc finger domain
- nuclear export signal receptor
- transporter
Pathways
Biological processes and signaling networks where the Nupl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nuclear pores
- nucleoplasm
- nuclear envelope
- photoreceptor outer segments
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nupl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleocytoplasmic transport
- protein export from nucleus
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- nuclear membrane
- cytosol
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- metal ion binding
- nuclear export signal receptor activity