Tsr1 Gene Summary [Mouse]
Predicted to enable GTP binding activity; GTPase activity; and U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus. Orthologous to human TSR1 (TSR1 ribosome maturation factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Tsr1 |
| Official Name | TSR1 20S rRNA accumulation [Source:MGI Symbol;Acc:MGI:2144566] |
| Ensembl ID | ENSMUSG00000038335 |
| Bio databases IDs | |
| Aliases | TSR1 20S rRNA accumulation |
| Synonyms | FLJ10534, mKIAA1401, TSR1 20S rRNA accumulation, TSR1 ribosome maturation factor, TSR1, ribosome maturation factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tsr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
- protein binding
- AARP2CN (NUC121) domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tsr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleolus
- preribosome, small subunit precursor
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- RNA binding
- GTPase activity
- U3 snoRNA binding