Nxt1 Gene Summary [Mouse]
Enables small GTPase binding activity. Acts upstream of or within RNA export from nucleus and protein export from nucleus. Part of nuclear pore. Is expressed in several structures, including central nervous system; gut; sensory organ; submandibular gland primordium; and tail dorsal root ganglion. Orthologous to human NXT1 (nuclear transport factor 2 like export factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nxt1 |
| Official Name | NTF2-related export protein 1 [Source:MGI Symbol;Acc:MGI:1929619] |
| Ensembl ID | ENSMUSG00000036992 |
| Bio databases IDs | |
| Aliases | NTF2-related export protein 1 |
| Synonyms | 1110001N02Rik, MTR2, NTF2-related export protein 1, nuclear transport factor 2-like export factor 1, P15, p15-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nxt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- protein binding
- NTF2_like
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nuclear pores
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nxt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- protein export from nucleus
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear RNA export factor complex
- cytoplasm
- nuclear speck
- cytosol
- nucleoplasm
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding