Tob2 Gene Summary [Mouse]
Enables nuclear vitamin D receptor binding activity. Acts upstream of or within negative regulation of osteoclast differentiation; positive regulation of ossification; and regulation of gene expression. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Meckel's cartilage; cerebral cortex; genitourinary system; lens; and orbito-sphenoid. Orthologous to human TOB2 (transducer of ERBB2, 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tob2 |
| Official Name | transducer of ERBB2, 2 [Source:MGI Symbol;Acc:MGI:1888525] |
| Ensembl ID | ENSMUSG00000048546 |
| Bio databases IDs | |
| Aliases | transducer of ERBB2, 2 |
| Synonyms | 2900090N22Rik, 4930545K18Rik, APRO5, mKIAA1663, TOB4, TOBL, transducer of ERBB2, 2, TROB2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tob2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTG family
- PABP binding domain
- vitamin D receptor binding
- protein binding
- tob/btg1 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- immune thrombocytopenia
role in cell
- differentiation
- proliferation
- G1/S phase transition
- ossification by
- RNA post-transciptional gene silencing in
- repression in
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tob2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female gamete generation
- osteoclast differentiation
- negative regulation of transcription, DNA-dependent
- negative regulation of cell proliferation
- negative regulation of osteoclast differentiation
- regulation of gene expression
- positive regulation of ossification
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity
- vitamin D receptor binding