Nanos2 Gene Summary [Mouse]
Enables mRNA binding activity. Involved in several processes, including germ-line stem cell population maintenance; mRNA catabolic process; and negative regulation of meiotic nuclear division. Located in P-body and perinuclear region of cytoplasm. Is expressed in early conceptus; gonad; mesonephros; and telencephalon. Orthologous to human NANOS2 (nanos C2HC-type zinc finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nanos2 |
| Official Name | nanos C2HC-type zinc finger 2 [Source:MGI Symbol;Acc:MGI:2676627] |
| Ensembl ID | ENSMUSG00000051965 |
| Bio databases IDs | |
| Aliases | nanos C2HC-type zinc finger 2 |
| Synonyms | nanos C2HC-type zinc finger 2, NOS2, RGD1562436, ZC2HC12B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nanos2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA binding
- protein binding
- enzyme activator activity
- Nanos RNA binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- perinuclear region
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nanos2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA destabilization
- oogenesis
- spermatogenesis
- germ-line stem cell maintenance
- mRNA catabolic process
- negative regulation of meiosis
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- mRNA binding
- enzyme activator activity