Hoxb3 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including hemopoiesis; nervous system development; and skeletal system development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; gut; and mesoderm. Orthologous to human HOXB3 (homeobox B3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxb3 |
| Official Name | homeobox B3 [Source:MGI Symbol;Acc:MGI:96184] |
| Ensembl ID | ENSMUSG00000048763 |
| Bio databases IDs | |
| Aliases | homeobox B3 |
| Synonyms | homeo box B3, HOX2, Hox-2.7, HOX2G |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Domain of unknown function (DUF4074)
- double-stranded DNA binding
- nucleic acid binding
- homeolike domain
- sequence-specific DNA binding
- homeodomain
Pathways
Biological processes and signaling networks where the Hoxb3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- insomnia
- glossopharyngeal-vagus nerve fusion
- acute myeloid leukemia
- diverticular disease
- cleft lip
- overnutrition
- Cornelia de Lange syndrome
role in cell
- proliferation
- number
- differentiation
- cell cycle progression
- colony formation
- quantity
- transcription in
- transactivation in
- morphogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glossopharyngeal nerve morphogenesis
- anterior/posterior pattern specification
- rhombomere development
- positive regulation of transcription from RNA polymerase II promoter
- face development
- hemopoietic progenitor cell differentiation
- embryonic skeletal system morphogenesis
- regulation of transcription from RNA polymerase II promoter
- definitive hemopoiesis
- negative regulation of transcription from RNA polymerase II promoter
- thyroid gland development
- angiogenesis
- regulation of neurogenesis
- cartilage development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity