Mafb Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including abducens nerve formation; cornified envelope assembly; and negative regulation of osteoclast differentiation. Acts upstream of or within several processes, including T cell differentiation in thymus; brain development; and thymus development. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Human ortholog(s) of this gene implicated in Duane retraction syndrome 3 and multicentric carpotarsal osteolysis syndrome. Orthologous to human MAFB (MAF bZIP transcription factor B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mafb |
| Official Name | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) [Source:MGI Symbol;Acc:MGI:104555] |
| Ensembl ID | ENSMUSG00000074622 |
| Bio databases IDs | |
| Aliases | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) |
| Synonyms | Basic domain/leucine zipper transcription factor, b-maf, DURS3, kr, Kreisler, KRML, Krml1, Maf1, MAF bZIP transcription factor B, MCTO |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mafb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- Maf N-terminal region
- transcription regulator
- Sumoylation motif
- nucleic acid binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- binding protein
- double-stranded DNA binding
- bZIP
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Mafb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteosarcoma
- duane retraction syndrome 3
- atherosclerosis
- hereditary disorder
- multicentric carpotarsal osteolysis syndrome
- cyanosis
- metastatic colorectal cancer
- dyspnea
- orofacial cleft 1
role in cell
- migration
- apoptosis
- expression in
- growth
- proliferation
- differentiation
- activation in
- production in
- quantity
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mafb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell differentiation in thymus
- brain segmentation
- abducens nerve formation
- regulation of transcription, DNA-dependent
- fat cell differentiation
- respiratory gaseous exchange
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of erythrocyte differentiation
- regulation of myeloid cell differentiation
- segment specification
- sensory organ development
- thymus development
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- keratinocyte differentiation
- rhombomere 5 development
- rhombomere 6 development
- positive regulation of transcription, DNA-dependent
- inner ear morphogenesis
- negative regulation of osteoclast differentiation
- protein processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity