Dact2 Gene Summary [Mouse]
Enables several functions, including beta-catenin binding activity; delta-catenin binding activity; and protein kinase C binding activity. Involved in several processes, including epithelial cell morphogenesis; inner medullary collecting duct development; and negative regulation of nodal signaling pathway. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and umbilical vein. Orthologous to human DACT2 (dishevelled binding antagonist of beta catenin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dact2 |
| Official Name | dishevelled-binding antagonist of beta-catenin 2 [Source:MGI Symbol;Acc:MGI:1920347] |
| Ensembl ID | ENSMUSG00000048826 |
| Bio databases IDs | |
| Aliases | dishevelled-binding antagonist of beta-catenin 2 |
| Synonyms | 2900084M21Rik, A630024E20, bA503C24.7, C6orf116, DAPPER2, Dapper homolog 2, antagonist of beta-catenin, Dapper homolog 2, antagonist of β-catenin, dishevelled-binding antagonist of beta-catenin 2, dishevelled-binding antagonist of β-catenin 2, DPR2, Frd2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dact2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- Dapper
- beta-catenin binding
- protein kinase C binding
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- WNT
- DLX2
disease
- cancer
- breast cancer
- lung cancer
- thoracic cancer
role in cell
- migration
- differentiation
- adhesion
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dact2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell adhesion
- epithelial cell morphogenesis
- skin development
- inner medullary collecting duct development
- negative regulation of nodal signaling pathway
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- delta-catenin binding
- beta-catenin binding
- transcription factor binding
- protein kinase A binding