Dlx2 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and single-stranded RNA binding activity. Involved in negative regulation of photoreceptor cell differentiation; positive regulation of amacrine cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including negative regulation of oligodendrocyte differentiation; nervous system development; and skeletal system development. Located in nucleus. Is expressed in several structures, including branchial arch; embryo ectoderm; genitourinary system; sensory organ; and tooth. Orthologous to human DLX2 (distal-less homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlx2 |
| Official Name | distal-less homeobox 2 [Source:MGI Symbol;Acc:MGI:94902] |
| Ensembl ID | ENSMUSG00000023391 |
| Bio databases IDs | |
| Aliases | distal-less homeobox 2 |
| Synonyms | DII A, distal-less homeobox 2, DLX-5, TES-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- Homeobox protein distal-less-like N terminal
- chromatin binding
- protein binding
- sequence-specific DNA binding
- single-stranded RNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- meteorism
- hypoperistalsis
- androgenic alopecia
- dyspnea
- cyanosis
role in cell
- activation in
- expression in
- signaling in
- apoptosis
- growth
- survival
- migration
- quantity
- loss
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- oligodendrocyte differentiation
- forebrain neuron differentiation
- subpallium development
- embryonic cranial skeleton morphogenesis
- positive regulation of cell differentiation
- branching morphogenesis of a nerve
- hippocampus development
- odontogenesis of dentin-containing tooth
- brain development
- negative regulation of photoreceptor cell differentiation
- negative regulation of Notch signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- olfactory bulb development
- cerebral cortex GABAergic interneuron fate commitment
- proximal/distal pattern formation
- negative regulation of oligodendrocyte differentiation
- negative regulation of transcription from RNA polymerase II promoter
- Notch signaling pathway
- cell differentiation
- cartilage development
- neuroblast differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- single-stranded RNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity