Dact1 Gene Summary [Mouse]
Enables delta-catenin binding activity; protein kinase A binding activity; and protein kinase C binding activity. Involved in several processes, including embryonic hindgut morphogenesis; negative regulation of JNK cascade; and regulation of Wnt signaling pathway. Acts upstream of or within several processes, including dendrite morphogenesis; negative regulation of canonical Wnt signaling pathway; and positive regulation of fat cell differentiation. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome. Orthologous to human DACT1 (dishevelled binding antagonist of beta catenin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dact1 |
| Official Name | dishevelled-binding antagonist of beta-catenin 1 [Source:MGI Symbol;Acc:MGI:1891740] |
| Ensembl ID | ENSMUSG00000044548 |
| Bio databases IDs | |
| Aliases | dishevelled-binding antagonist of beta-catenin 1 |
| Synonyms | 4921528D17Rik, DAPPER, DAPPER1, dishevelled-binding antagonist of beta-catenin 1, dishevelled-binding antagonist of β-catenin 1, DPR1, Frd1, FRODO, Frodo1, HDPR1, MDpr1, MTNG3, RGD1564008, TBS2, THYEX3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dact1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- Dapper
- beta-catenin binding
- protein kinase C binding
- transcription factor binding
- histone deacetylase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- infiltrating ductal breast carcinoma
- breast ductal carcinoma in situ
- ductal in situ breast cancer
- atresia
- hydronephrosis
- hypoplasia
- hydrometrocolpos
- caudal agenesis
- Townes-Brocks syndrome 2
role in cell
- migration
- expression in
- degradation in
- accumulation in
- invasion by
- binding in
- cell proliferation
- signaling in
- ubiquitination in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dact1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- positive regulation of protein binding
- embryonic hindgut morphogenesis
- regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of protein catabolic process
- negative regulation of JNK cascade
- negative regulation of protein binding
- regulation of nodal signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- regulation of protein stability
- regulation of canonical Wnt receptor signaling pathway
- negative regulation of G1/S transition of mitotic cell cycle
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- beta-catenin destruction complex
- nucleus
- cytoplasm
- cytosol
- synapse
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- delta-catenin binding
- protein binding
- histone deacetylase binding
- beta-catenin binding
- protein kinase A binding