Phf3 Gene Summary [Mouse]
Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human PHF3 (PHD finger protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phf3 |
| Official Name | PHD finger protein 3 [Source:MGI Symbol;Acc:MGI:2446126] |
| Ensembl ID | ENSMUSG00000048874 |
| Bio databases IDs | |
| Aliases | PHD finger protein 3 |
| Synonyms | 2310061N19RIK, AU018519, AU020177, LOC213109, PHD finger protein 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPOC (Spen paralog and ortholog C-terminal) domain superfamily
- PHD zinc finger
- Transcription factor S-II (TFIIS), central domain
- SPOC domain
- PHD finger superfamily
- Transcription factor S-II M domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- lung squamous cell carcinoma
- schizophrenia
- Tourette syndrome
- Alzheimer disease
- major depression
- primary antiphospholipid antibody syndrome
- infection by HIV-1
regulated by
- KRAS
- GH1
- Pc 3 cells
role in cell
- checkpoint recovery in
- mitotic entry in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- metal ion binding