Zadh2 Gene Summary [Mouse]
Enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Involved in negative regulation of fat cell differentiation. Located in peroxisome. Orthologous to human PTGR3 (prostaglandin reductase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zadh2 |
| Official Name | zinc binding alcohol dehydrogenase, domain containing 2 [Source:MGI Symbol;Acc:MGI:2444835] |
| Ensembl ID | ENSMUSG00000049090 |
| Bio databases IDs | |
| Aliases | zinc binding alcohol dehydrogenase, domain containing 2 |
| Synonyms | C530046K17Rik, PRG-3, prostaglandin reductase 3, Pthr3, ZADH2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zadh2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 15-oxoprostaglandin 13-oxidase
- putative NAD(P)H quinone oxidoreductase, PIG3 family
- MDR
- Zinc-binding dehydrogenase
- putative quinone oxidoreductase, YhdH/YhfP family
- Alcohol dehydrogenase GroES-like domain
- enzyme
- Enoylreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zadh2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fat cell differentiation
- prostaglandin metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- 13-prostaglandin reductase activity
- 15-oxoprostaglandin 13-oxidase activity