Cks2 Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within several processes, including fibroblast proliferation; mitotic cell cycle phase transition; and regulation of transcription by RNA polymerase II. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Is expressed in branchial arch; cerebellum; and telencephalon. Orthologous to human CKS2 (CDC28 protein kinase regulatory subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cks2 |
| Official Name | CDC28 protein kinase regulatory subunit 2 [Source:MGI Symbol;Acc:MGI:1913447] |
| Ensembl ID | ENSMUSG00000062248 |
| Bio databases IDs | |
| Aliases | CDC28 protein kinase regulatory subunit 2 |
| Synonyms | 1110038L14Rik, CDC28 protein KINASE REGULATORY subunit 2, CDC28 REGULATORY subunit 2, CKSHS2, P13SUC1, RGD1562047 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cks2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- chromatin binding
- protein binding
- Cyclin-dependent kinase regulatory subunit
Pathways
Biological processes and signaling networks where the Cks2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- papillary thyroid carcinoma
- epithelial cancer
- liver cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- androgenic alopecia
- organismal death
- HER2 negative hormone receptor negative breast cancer
- diffuse cutaneous systemic sclerosis
role in cell
- growth
- migration
- proliferation
- invasion by
- expression in
- apoptosis
- cell viability
- number
- colony formation
- S phase checkpoint control
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cks2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- fibroblast proliferation
- regulation of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
- meiosis I
Cellular Component
Where in the cell the gene product is active
- cyclin-dependent protein kinase holoenzyme complex
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- ubiquitin binding
- histone binding
- chromatin binding