Nedd4l Gene Summary [Mouse]
Enables sodium channel inhibitor activity and ubiquitin protein ligase activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization; regulation protein catabolic process at postsynapse; and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including negative regulation of systemic arterial blood pressure; regulation of bicellular tight junction assembly; and regulation of monoatomic ion transport. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and retina. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nedd4l |
| Official Name | neural precursor cell expressed, developmentally down-regulated gene 4-like [Source:MGI Symbol;Acc:MGI:1933754] |
| Ensembl ID | ENSMUSG00000024589 |
| Bio databases IDs | |
| Aliases | neural precursor cell expressed, developmentally down-regulated gene 4-like |
| Synonyms | 1300012C07Rik, hNEDD4-2, NEDD4-2, NEDD4.2, Nedd4b, NEDD4 like E3 ubiquitin protein ligase, neural precursor cell expressed, developmentally down-regulated gene 4-like, PVNH7, RSP5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nedd4l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- potassium channel regulator
- Domain Homologous to E6-AP Carboxyl Terminus with
- WW class I binding domain
- sodium channel regulator
- enzyme
- protein binding
- potassium channel inhibitor
- WW domain
- sodium channel inhibitor
- HECTc
- ubiquitin ligase-like domain
- Domain with 2 conserved Trp (W) residues
- ubiquitin-protein transferase activity
- WW
- active site
- ion channel binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Pathways
Biological processes and signaling networks where the Nedd4l gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mental retardation
- major depression
- neoplasia
- metastasis
- periventricular nodular heterotopia type 7
- survival
- periventricular nodular heterotopia 5
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- heart failure
- organismal death
role in cell
- activation in
- expression in
- invasion by
- phosphorylation in
- transmembrane potential
- number
- proliferation
- ubiquitination in
- production in
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cell surface
- Plasma Membrane
- Golgi Apparatus
- cytosol
- apical membrane
- endosomal membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nedd4l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- ion transmembrane transport
- regulation of ventricular cardiac muscle cell action potential
- regulation of membrane repolarization
- positive regulation of protein catabolic process
- regulation of membrane depolarization
- protein monoubiquitination
- regulation of dendrite morphogenesis
- ubiquitin-dependent protein catabolic process
- negative regulation of protein localization at cell surface
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of membrane potential
- regulation of protein stability
- regulation of ion transmembrane transport
- cell differentiation
- positive regulation of caveolin-mediated endocytosis
- negative regulation of sodium ion transmembrane transporter activity
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- Golgi apparatus
- multivesicular body
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- ubiquitin-protein ligase activity
- protein binding
- potassium channel inhibitor activity
- sodium channel inhibitor activity
- potassium channel regulator activity
- ion channel binding