Nrap Gene Summary [Mouse]
Enables actin binding activity; muscle alpha-actinin binding activity; and vinculin binding activity. Predicted to be involved in cardiac muscle thin filament assembly. Predicted to act upstream of or within actin cytoskeleton organization. Located in fascia adherens; muscle tendon junction; and myofibril. Is expressed in early conceptus; heart; limb musculature; oocyte; and skeletal muscle. Orthologous to human NRAP (nebulin related anchoring protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrap |
| Official Name | nebulin-related anchoring protein [Source:MGI Symbol;Acc:MGI:1098765] |
| Ensembl ID | ENSMUSG00000049134 |
| Bio databases IDs | |
| Aliases | nebulin-related anchoring protein |
| Synonyms | Nebulin-related, nebulin-related anchoring protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nebulin-like super repeat domain
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- actinin binding
- actin binding
- vinculin binding
- protein binding
- Nebulin repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- actin filaments
- myofibrils
- cell-cell adherens junctions
- cell-matrix adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cardiac muscle thin filament assembly
Cellular Component
Where in the cell the gene product is active
- Z disc
- fascia adherens
- muscle tendon junction
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- actin binding
- metal ion binding
- muscle alpha-actinin binding
- vinculin binding