Magt1 Gene Summary [Mouse]
Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in cognition; magnesium ion transport; and protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Used to study primary immunodeficiency disease. Human ortholog(s) of this gene implicated in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia and congenital disorder of glycosylation Icc. Orthologous to human MAGT1 (magnesium transporter 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Magt1 |
| Official Name | magnesium transporter 1 [Source:MGI Symbol;Acc:MGI:1914325] |
| Ensembl ID | ENSMUSG00000031232 |
| Bio databases IDs | |
| Aliases | magnesium transporter 1 |
| Synonyms | 2410001C15Rik, 2610529C04RIK, 2810482I07Rik, bA217H1.1, CDG1CC, DKFZp564K142, IAG2, IAP, implantation-associated, magnesium transporter 1, MRX95, OST3B, PRO0756, SLC58A1, XMEN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Magt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- magnesium ion transporter
- OST3 / OST6 family, transporter family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type 1CC
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- aldosterone producing adrenocortical adenoma
- adenoma formation
- Graves disease
- idiopathic CD4+ T-lymphocytopenia
- congenital disorders of glycosylation
- X-linked mental retardation
- infection by bacteria
role in cell
- cell viability
- expression in
- activation in
- phosphorylation in
- activation
- dephosphorylation in
- frequency
- N-glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
- secretory granule membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Magt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- cognition
- magnesium ion transport
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- oligosaccharyltransferase complex
- membrane
- endoplasmic reticulum
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion transmembrane transporter activity