Ctu2 Gene Summary [Mouse]
Predicted to enable sulfurtransferase activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Is expressed in ovary and primary sex cord. Orthologous to human CTU2 (cytosolic thiouridylase subunit 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctu2 |
| Official Name | cytosolic thiouridylase subunit 2 [Source:MGI Symbol;Acc:MGI:1914215] |
| Ensembl ID | ENSMUSG00000049482 |
| Bio databases IDs | |
| Aliases | cytosolic thiouridylase subunit 2 |
| Synonyms | 2310061F22Rik, C16orf84, cytosolic thiouridylase subunit 2, Loc292069, MFRG, NCS2, UPF0432 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctu2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Cytoplasmic tRNA 2-thiolation protein 2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- invasive ductal breast cancer
- microcephaly, facial dysmorphism, renal agenesis, and ambiguous genitalia syndrome
- congenital anomalies of kidney and urinary tract
- breast ductal carcinoma in situ
- ductal in situ breast cancer
- microcephaly
regulated by
- REL
- cocaine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctu2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA wobble uridine modification
- protein urmylation
- tRNA wobble position uridine thiolation
- tRNA thio-modification
Cellular Component
Where in the cell the gene product is active
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- protein binding
- sulfurtransferase activity
- tRNA binding