Ajuba

Enables several functions, including actin filament binding activity; alpha-catenin binding activity; and transcription corepressor activity. Involved in positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; focal adhesion assembly; and regulation of kinase activity. Located in several cellular components, including cytosol; focal adhesion; and lamellipodium. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; jaw; sensory organ; and telencephalon. Orthologous to human AJUBA (ajuba LIM protein). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ajuba often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Ajuba gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ajuba gene, providing context for its role in the cell.