Klhl20 Gene Summary [Mouse]
Predicted to enable type II interferon binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including Golgi to endosome transport; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K33-linked ubiquitination. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in PML body and trans-Golgi network. Is expressed in cranial ganglion; dorsal root ganglion; hindbrain; and thymus primordium. Orthologous to human KLHL20 (kelch like family member 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl20 |
| Official Name | kelch-like 20 [Source:MGI Symbol;Acc:MGI:2444855] |
| Ensembl ID | ENSMUSG00000026705 |
| Bio databases IDs | |
| Aliases | kelch-like 20 |
| Synonyms | AB026190, D930050H05RIK, kelch-like 20, kelch-like family member 20, KELCH-LIKE protein X, KHLHX, KLEIP, KLHLX, mKIAA4210, RGD1309490 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kelch motif
- BTB_POZ
- enzyme
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Galactose oxidase, central domain
- actin-binding domain
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- ubiquitin-protein transferase activity
- BTB/POZ domain
- interferon-gamma binding
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mammary neoplasm
- mental retardation
- neurodevelopmental disorder
- schizophrenia
role in cell
- apoptosis
- proliferation
- migration
- degradation in
- organization
- polyubiquitination in
- ubiquitination in
- sprouting angiogenesis
- TAK-901 resistance
- JG-231 resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- actin cytoskeleton
- Golgi Apparatus
- cytosol
- trans Golgi network
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- cytoskeleton organization
- negative regulation of apoptotic process
- protein transport
- response to interferon-alpha
- Golgi to endosome transport
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- dendrite
- trans-Golgi network
- perinuclear region of cytoplasm
- PML body
- cytoplasm
- actin cytoskeleton
- cytosol
- Golgi apparatus
- Cul3-RING ubiquitin ligase complex
- axon
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- actin binding
- interferon-gamma binding