Tsku Gene Summary [Mouse]
Enables transforming growth factor beta binding activity. Involved in several processes, including cholesterol efflux; cholesterol homeostasis; and neuron projection development. Acts upstream of or within several processes, including ciliary body morphogenesis; negative regulation of Wnt signaling pathway; and telencephalon development. Located in extracellular space. Is expressed in several structures, including olfactory epithelium and skin. Orthologous to human TSKU (tsukushi, small leucine rich proteoglycan). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tsku |
| Official Name | tsukushi, small leucine rich proteoglycan [Source:MGI Symbol;Acc:MGI:2443855] |
| Ensembl ID | ENSMUSG00000049580 |
| Bio databases IDs | |
| Aliases | tsukushi, small leucine rich proteoglycan |
| Synonyms | 9530051K01Rik, E2IG4, Eiih, LRRC54, TSK, tsukushi, small leucine rich proteoglycan |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tsku often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- protein binding
- TGFbeta binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- venous thromboembolism
- hip or knee osteoarthritis
- non-insulin-dependent diabetes mellitus
- ischemic stroke
- osteoarthritis
- major depression
- metabolic syndrome X
regulates
- cholesterol
- Collagen(s)
- TGFB1
role in cell
- differentiation
- organization
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tsku gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of hair cycle
- inner ear receptor stereocilium organization
- cholesterol metabolic process
- hippocampus development
- corpus callosum morphogenesis
- growth plate cartilage chondrocyte development
- cholesterol homeostasis
- anterior commissure morphogenesis
- wound healing
- negative regulation of transforming growth factor beta1 production
- lateral ventricle development
- negative regulation of neuron projection development
- camera-type eye development
- energy homeostasis
- regulation of gene expression
- cholesterol efflux
- negative regulation of Wnt receptor signaling pathway
- ciliary body morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- transforming growth factor beta binding