Uxs1 Gene Summary [Mouse]
Predicted to enable NAD+ binding activity; UDP-glucuronate decarboxylase activity; and protein homodimerization activity. Predicted to be involved in UDP-D-xylose biosynthetic process. Located in mitochondrion. Is expressed in forelimb and hindlimb. Orthologous to human UXS1 (UDP-glucuronate decarboxylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uxs1 |
| Official Name | UDP-glucuronate decarboxylase 1 [Source:MGI Symbol;Acc:MGI:1915133] |
| Ensembl ID | ENSMUSG00000057363 |
| Bio databases IDs | |
| Aliases | UDP-glucuronate decarboxylase 1 |
| Synonyms | 1600025I13Rik, FLJ23591, hUXS, hUXS1, SDR6E1, UDP-glucuronate decarboxylase 1, UGD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uxs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- NAD or NADH binding
- TIGR01777 family protein
- binding protein
- ADP-L-glycero-D-manno-heptose-6-epimerase
- UDP-glucuronate decarboxylase N-terminal
- NAD dependent epimerase/dehydratase family
- protein homodimerization
- enzyme
- identical protein binding
- UDPglucuronate decarboxylase
- GDP-mannose 4,6 dehydratase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi lumen
- perinuclear Golgi regions
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uxs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- UDP-D-xylose biosynthetic process
- D-xylose metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- Golgi cisterna membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- UDP-glucuronate decarboxylase activity
- NAD+ binding