Hic2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Is expressed in central nervous system; extraembryonic component; female reproductive system; heart; and urinary system. Orthologous to human HIC2 (HIC ZBTB transcriptional repressor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hic2 |
| Official Name | hypermethylated in cancer 2 [Source:MGI Symbol;Acc:MGI:1929869] |
| Ensembl ID | ENSMUSG00000050240 |
| Bio databases IDs | |
| Aliases | hypermethylated in cancer 2 |
| Synonyms | Hic-3, HIC ZBTB transcriptional repressor 2, HRG22, hypermethylated in cancer 2, LOC124908408, mKIAA1020, ZBTB30, ZNF907 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hic2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- Broad-Complex, Tramtrack and Bric a brac
- Zinc-finger double domain
- BTB_POZ
- BTB/POZ domain
- protein binding
- C2H2-type zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hic2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- regulation of cytokine production
- regulation of immune system process
Cellular Component
Where in the cell the gene product is active
- nucleus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription