Pdk2 Gene Summary [Mouse]
Enables pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including glucose homeostasis; insulin receptor signaling pathway; and regulation of small molecule metabolic process. Acts upstream of or within regulation of calcium-mediated signaling. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Is expressed in aorta; cerebral cortex; cerebral cortex subventricular zone; heart; and liver. Orthologous to human PDK2 (pyruvate dehydrogenase kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdk2 |
| Official Name | pyruvate dehydrogenase kinase, isoenzyme 2 [Source:MGI Symbol;Acc:MGI:1343087] |
| Ensembl ID | ENSMUSG00000038967 |
| Bio databases IDs | |
| Aliases | pyruvate dehydrogenase kinase, isoenzyme 2 |
| Synonyms | LOC100506500, PDHK2, PDKII, Pyruvate dehydrogenase kinase 2, pyruvate dehydrogenase kinase, isoenzyme 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- Histidine kinase-like ATPase domain
- [pyruvate dehydrogenase (lipoamide)] kinase
- ATP binding
- protein binding
- identical protein binding
- Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
- kinase
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- binding protein
- protein homodimerization
- Histidine kinase-like ATPases
Pathways
Biological processes and signaling networks where the Pdk2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- edema
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- Huntington disease
- microvesicular hepatic steatosis
- thermal hyperalgesia
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- expression in
- phosphorylation in
- cell death
- activation
- response by
- gluconeogenesis in
- infiltration by
- glycolysis in
- autophagy in
- depletion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin receptor signaling pathway
- cellular response to nutrient
- regulation of gluconeogenesis
- protein phosphorylation
- glucose metabolic process
- regulation of pH
- regulation of glucose metabolic process
- signal transduction by p53 class mediator resulting in induction of apoptosis
- glucose homeostasis
- regulation of calcium-mediated signaling
- cellular response to reactive oxygen species
- regulation of cellular ketone metabolic process
- regulation of acetyl-CoA biosynthetic process from pyruvate
Cellular Component
Where in the cell the gene product is active
- pyruvate dehydrogenase complex
- mitochondrial matrix
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein homodimerization activity
- protein binding
- protein kinase activity
- pyruvate dehydrogenase (acetyl-transferring) kinase activity