Trim71 Gene Summary [Mouse]
Enables miRNA binding activity and ubiquitin protein ligase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; miRNA-mediated gene silencing by inhibition of translation; and protein autoubiquitination. Acts upstream of or within neural tube closure; positive regulation of miRNA-mediated gene silencing; and regulation of protein metabolic process. Located in P-body. Is expressed in several structures, including branchial arch; extraembryonic component; limb bud; nervous system; and reproductive system. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human TRIM71 (tripartite motif containing 71). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim71 |
| Official Name | tripartite motif-containing 71 [Source:MGI Symbol;Acc:MGI:2685973] |
| Ensembl ID | ENSMUSG00000079259 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 71 |
| Synonyms | 2610206G21RIK, AL022943, Gm1127, HYC4, HYDCC1, LIN-41, mLin41, RGD1566388, tripartite motif-containing 71 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim71 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- SMP-30/Gluconolactonase/LRE-like region
- Filamin/ABP280 repeat
- B-Box C-terminal domain
- translation repressor
- ubiquitin protein ligase activity
- enzyme
- protein binding
- NHL repeat unit of beta-propeller proteins
- RNA binding
- B-box-type zinc finger superfamily
- NHL repeat
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- B-box zinc finger
- Filamin-type immunoglobulin domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital communicating hydrocephalus type 1
- colorectal cancer
- congenital hydrocephalus
role in cell
- activation in
- proliferation
- formation
- differentiation
- binding in
- quantity
- camptothecin sensitivity
- dichloroacetic acid sensitivity
- neural cell differentiation
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim71 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- 3'-UTR-mediated mRNA destabilization
- negative regulation of translation involved in gene silencing by miRNA
- protein polyubiquitination
- production of miRNAs involved in gene silencing by miRNA
- fibroblast growth factor receptor signaling pathway
- posttranscriptional regulation of gene expression
- proteasomal ubiquitin-dependent protein catabolic process
- neural tube closure
- positive regulation of gene silencing by miRNA
- stem cell proliferation
- G1/S transition of mitotic cell cycle
- regulation of neural precursor cell proliferation
- negative regulation of translation
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- translation repressor activity