Prickle3 Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Predicted to be involved in cell projection organization. Located in mitochondrion. Is expressed in several structures, including ear; early conceptus; female reproductive system; lower urinary tract; and nervous system. Used to study Leber plus disease. Orthologous to human PRICKLE3 (prickle planar cell polarity protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prickle3 |
| Official Name | prickle planar cell polarity protein 3 [Source:MGI Symbol;Acc:MGI:1859635] |
| Ensembl ID | ENSMUSG00000031145 |
| Bio databases IDs | |
| Aliases | prickle planar cell polarity protein 3 |
| Synonyms | LMO6, LOAM, LOAS, Pk3, prickle planar cell polarity protein 3, Sfc16 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prickle3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- PET domain
- protein binding
- PET (Prickle Espinas Testin)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prickle3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell projection organization
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding