Hoxc12 Gene Summary [Mouse]
Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including genitourinary system; integumental system; jaw; limb; and spinal cord. Orthologous to human HOXC12 (homeobox C12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxc12 |
| Official Name | homeobox C12 [Source:MGI Symbol;Acc:MGI:96194] |
| Ensembl ID | ENSMUSG00000050328 |
| Bio databases IDs | |
| Aliases | homeobox C12 |
| Synonyms | HOC3F, homeo box C12, HOX3, Hox-3.8, HOX3F |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxc12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxc12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding RNA polymerase II transcription factor activity