Hotair Gene Summary [Mouse]
A long non-coding RNA is transcribed from this gene. The same as human gene, this gene is located between Hoxc11 and Hoxc12 genes in the Hoxc gene cluster. This gene is not conserved in sequence, and differently from the human gene, its absence has little effect on transcription efficiency of the Hoxd gene cluster. [provided by RefSeq, Apr 2012]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | Hotair |
| Official Name | HOX transcript antisense RNA (non-protein coding) [Source:MGI Symbol;Acc:MGI:3826586] |
| Ensembl ID | ENSMUSG00000086903 |
| Bio databases IDs | |
| Aliases | HOX transcript antisense RNA (non-protein coding) |
| Synonyms | FLJ41747, Gm16258, HOXAS, HOXC11-AS1, HOXC-AS4, HOX transcript antisense RNA, HOX transcript antisense RNA (non-protein coding), NCRNA00072 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hotair often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastric cancer
- metastasis
- gastric carcinoma
- gastric epithelial cancer
- metastatic breast cancer
- hepatic fibrosis
- carbon tetrachloride-induced liver fibrosis
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- growth
- cell viability
- expression in
- migration
- proliferation
- apoptosis
- phosphorylation in
- accumulation in
- cell death
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome