Lrrc4c Gene Summary [Mouse]
Predicted to enable cell-cell adhesion mediator activity. Involved in modulation of chemical synaptic transmission and synaptic membrane adhesion. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in central nervous system and eye. Orthologous to human LRRC4C (leucine rich repeat containing 4C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrc4c |
| Official Name | leucine rich repeat containing 4C [Source:MGI Symbol;Acc:MGI:2442636] |
| Ensembl ID | ENSMUSG00000050587 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 4C |
| Synonyms | 6430556C10RIK, KIAA1580, leucine rich repeat containing 4C, NGL-1, RGD1311013 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrrc4c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- Immunoglobulin V-Type
- immunoglobulin domain
- cell adhesion molecule binding
- Immunoglobulin I-set domain
- Leucine rich repeat
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- cytoplasmic domain
- Immunoglobulin like
- Leucine rich repeat N-terminal domain
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Lrrc4c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- central nervous system cancer
- psychosis
- ischemic stroke
- COVID-19
- myopia
- prostate cancer
- chronic fatigue syndrome
- colorectal cancer
- covid-19 death
regulates
role in cell
- outgrowth
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell surface
- cellular membrane
- synaptic membrane
- dendritic spines
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrrc4c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of axonogenesis
- regulation of synaptic transmission
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cell adhesion molecule binding