Phospho1 Gene Summary [Mouse]
Predicted to enable phosphocholine phosphatase activity; phosphoethanolamine phosphatase activity; and pyrophosphatase activity. Involved in bone mineralization. Acts upstream of or within bone mineralization involved in bone maturation and endochondral ossification. Located in extracellular matrix and extracellular membrane-bounded organelle. Is expressed in several structures, including jaw; limb; liver; skeleton; and spleen. Orthologous to human PHOSPHO1 (phosphoethanolamine/phosphocholine phosphatase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phospho1 |
| Official Name | phosphatase, orphan 1 [Source:MGI Symbol;Acc:MGI:2447348] |
| Ensembl ID | ENSMUSG00000050860 |
| Bio databases IDs | |
| Aliases | phosphatase, orphan 1 |
| Synonyms | D11Moh36, Phos1, phosphatase, orphan 1, phosphoethanolamine/phosphocholine phosphatase 1, Phospo1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phospho1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pyrophosphatase
- Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like
- phosphatase
- enzyme
- protein binding
- 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
- Haloacid Dehalogenase-like Hydrolases
- haloacid dehalogenase-like hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonobstructive azoospermia
- rotator cuff injury
- chronic lymphocytic leukemia
role in cell
- expression in
- number
- endochondral ossification by
- catabolism in
- glycolysis in
- oxidative phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- organelle
- cytosol
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phospho1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone mineralization involved in bone maturation
- bone mineralization
- endochondral ossification
- regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- extracellular membrane-bounded organelle
- cytosol
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- phosphocholine phosphatase activity
- phosphoethanolamine phosphatase activity
- protein binding
- metal ion binding
- phosphatase activity
- pyrophosphatase activity