Pgrmc1 Gene Summary [Mouse]
Enables heme binding activity. Predicted to be involved in several processes, including learning or memory; modification of synaptic structure; and positive regulation of protein localization. Located in mitochondrial outer membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study metabolic dysfunction-associated steatotic liver disease. Orthologous to human PGRMC1 (progesterone receptor membrane component 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgrmc1 |
| Official Name | progesterone receptor membrane component 1 [Source:MGI Symbol;Acc:MGI:1858305] |
| Ensembl ID | ENSMUSG00000006373 |
| Bio databases IDs | |
| Aliases | progesterone receptor membrane component 1 |
| Synonyms | 25-Dx, Dap1, HPR6.6, IZA, Membrane-Associated Progesterone Receptor Component, MPR, PGRMC, PPMR, Prmc1, progesterone receptor membrane component 1, VEMA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pgrmc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cytochrome b5-like Heme/Steroid binding domain
- protein homodimerization
- protein binding
- heme binding
- beta-amyloid binding
- transmembrane receptor
- steroid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- Huntington disease
- familial premature ovarian failure
- autosomal dominant Emery-Dreifuss muscular dystrophy
role in cell
- cell death
- expression in
- activation in
- migration
- growth
- degradation in
- cell viability
- formation in
- phosphorylation in
- clearance in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- Cytoplasm
- cell surface
- intracellular space
- Endoplasmic Reticulum
- specific granule membrane
- plasma membrane extracellular face
- Golgi membrane
- mitochondrial outer membrane
- neurites
- synapse
- microsomal membrane
- perikaryon
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pgrmc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heme biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- synapse
- neuronal cell body
- extracellular region
- mitochondrial outer membrane
- neuron projection
- plasma membrane
- smooth endoplasmic reticulum membrane
- membrane
- cell body
- endomembrane system
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- metal ion binding
- steroid binding
- beta-amyloid binding
- heme binding