Hspe1 Gene Summary [Mouse]
Predicted to enable metal ion binding activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Located in mitochondrion. Is expressed in brain; brainstem nucleus; early conceptus; and midbrain ventricular layer. Orthologous to human HSPE1 (heat shock protein family E (Hsp10) member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspe1 |
| Official Name | heat shock protein 1 (chaperonin 10) [Source:MGI Symbol;Acc:MGI:104680] |
| Ensembl ID | ENSMUSG00000073676 |
| Bio databases IDs | |
| Aliases | heat shock protein 1 (chaperonin 10) |
| Synonyms | CHAPERONIN 10, CPN10, EARLY PREGNANCY FACTOR, EPF, GROES, heat shock protein 1 (chaperonin 10), heat shock protein family E (Hsp10) member 1, HSP10, mt-cpn10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hspe1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cpn10
- enzyme
- protein binding
- chaperone binding
Pathways
Biological processes and signaling networks where the Hspe1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lupus erythematosus
- colon carcinoma
- colon epithelial cancer
- psoriasis
role in cell
- apoptosis
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cellular membrane
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
- peroxisomes
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hspe1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoblast differentiation
- chaperone mediated protein folding requiring cofactor
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- protein folding
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- membrane
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- RNA binding
- protein binding involved in protein folding
- metal ion binding
- chaperone binding
- unfolded protein binding