Psph Gene Summary [Mouse]
Predicted to enable L-phosphoserine phosphatase activity; magnesium ion binding activity; and protein homodimerization activity. Acts upstream of or within in utero embryonic development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; liver; and urinary system. Human ortholog(s) of this gene implicated in PSPH deficiency. Orthologous to human PSPH (phosphoserine phosphatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psph |
| Official Name | phosphoserine phosphatase [Source:MGI Symbol;Acc:MGI:97788] |
| Ensembl ID | ENSMUSG00000029446 |
| Bio databases IDs | |
| Aliases | phosphoserine phosphatase |
| Synonyms | CL-3 PHOSPHOSERINE PHOSPHATASE, phosphoserine phosphatase, PSP, PSPase, PSPHD, Serb |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psph often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like
- phosphoserine phosphatase SerB
- phosphatase
- protein homodimerization
- magnesium ion binding
- identical protein binding
- Haloacid Dehalogenase-like Hydrolases
- haloacid dehalogenase-like hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- histone H3
- agar
- NR4A1
- L-serine
- 5-hydroxymethylcytosine
- L-serine-O-phosphate
- alpha-hydroxyglutarate
disease
- neoplasia
- metastasis
- glioma cancer
- glioma formation
- melanoma cancer
- organismal death
- high grade glioma
- deficiency of phosphoserine phosphatase
- cutaneous melanoma cancer
- chronic lymphocytic leukemia
phenotypes
- abnormal abdominal wall morphology
- abnormal craniofacial morphology
- abnormal embryo size
- abnormal eye morphology
- abnormal heart morphology
- abnormal placenta size
- abnormal skin coloration
- cardiovascular system phenotype
- decreased circulating triglyceride level
- decreased erythrocyte cell number
- increased circulating aspartate transaminase level
- increased circulating bilirubin level
- increased heart rate variability
- pallor
- preweaning lethality complete penetrance
- small adrenal glands
- thrombocytopenia
- abnormal Wolffian duct morphology
- abnormal adenohypophysis morphology
- abnormal bile duct morphology
- abnormal brain commissure morphology
- abnormal brain internal capsule morphology
- abnormal choroid plexus morphology
- abnormal dorsal root ganglion topology
- abnormal ductus venosus valve topology
- abnormal duodenum topology
- abnormal external auditory canal morphology
- abnormal eye muscle morphology
- abnormal facial nerve topology
- abnormal femur morphology
- abnormal forebrain morphology
- abnormal hindbrain morphology
- abnormal hypoglossal nerve topology
- abnormal inferior vena cava morphology
- abnormal infrahyoid muscle connection
- abnormal interatrial septum morphology
- abnormal larynx morphology
- abnormal lens morphology
- abnormal midbrain morphology
- abnormal middle ear ossicle morphology
- abnormal nasal cavity morphology
- abnormal nasal septum morphology
- abnormal neurohypophysis morphology
- abnormal olfactory bulb morphology
- abnormal olfactory nerve morphology
- abnormal optic cup morphology
- abnormal optic stalk morphology
- abnormal oral cavity morphology
- abnormal outer ear morphology
- abnormal parasellar internal carotid artery branch morphology
- abnormal pelvic girdle bone morphology
- abnormal pineal gland morphology
- abnormal placenta morphology
- abnormal placental labyrinth vasculature morphology
- abnormal posterior semicircular canal morphology
- abnormal pulmonary artery origin
- abnormal salivary gland morphology
- abnormal semicircular canal morphology
- abnormal sinus arrhythmia
- abnormal sphenoid bone morphology
- abnormal spinal cord central canal morphology
- abnormal thymus morphology
- abnormal thymus topology
- abnormal thyroid gland morphology
- abnormal trophoblast layer morphology
- abnormal vertebral artery origin
- abnormal vertebral body morphology
- abnormal vitelline vein connection
- abnormal vomeronasal organ morphology
- absent abducens nerve
- absent brain internal capsule
- absent celiac artery
- absent connection between subcutaneous lymph vessels and lymph sac
- absent external auditory canal
- absent eye muscles
- absent hypoglossal nerve
- absent maxilla
- absent neurohypophysis
- absent olfactory bulb
- absent olfactory nerve
- absent optic chiasm
- absent pineal gland
- absent portal vein segment
- absent posterior commissure
- absent salivary gland
- absent segment of posterior cerebral artery
- absent stapedial artery
- absent tongue
- absent trochlear nerve
- absent vomeronasal organ
- anastomosis between middle cerebral arteries
- aorta coarctation
- aphakia
- athymia
- basal brain tissue herniation
- blood in lymph vessels
- double outlet right ventricle
- embryo cyst
- embryonic growth retardation
- epithelioid cysts
- fetal growth retardation
- fragmented Meckel's cartilage
- fusion of vertebral arches
- fusion of vertebral bodies
- herniated liver
- heterochrony
- holoprosencephaly
- increased rib number
- intestinal/bowel diverticulum
- intraembryonal intestine elongation
- muscular ventricular septal defect
- oligodactyly
- perimembraneous ventricular septal defect
- persistent trigeminal artery
- persistent truncus arteriosis
- placenta hemorrhage
- placenta necrosis
- rib fusion
- short Meckel's cartilage
- small kidney
- small placenta
- small salivary gland
- small superior cervical ganglion
- spleen hypoplasia
- subcutaneous edema
- thin cerebral cortex
- thoracoschisis
- tongue hypoplasia
- trigeminal neuroma
- umbilical vein stenosis
role in cell
- expression in
- growth
- invasion by
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psph gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- L-serine metabolic process
- L-serine biosynthetic process
- response to testosterone stimulus
- dephosphorylation
- response to nutrient levels
- response to mechanical stimulus
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- identical protein binding
- protein homodimerization activity