Mtcl1 Gene Summary [Mouse]
Enables microtubule binding activity and protein homodimerization activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity; microtubule bundle formation; and positive regulation of protein targeting to membrane. Located in several cellular components, including apicolateral plasma membrane; cytoskeleton; and lateral plasma membrane. Is expressed in several structures, including alimentary system; cranial ganglion; limb segment; metanephros; and neural ectoderm. Orthologous to human MTCL1 (microtubule crosslinking factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtcl1 |
| Official Name | microtubule crosslinking factor 1 [Source:MGI Symbol;Acc:MGI:1915867] |
| Ensembl ID | ENSMUSG00000052105 |
| Bio databases IDs | |
| Aliases | microtubule crosslinking factor 1 |
| Synonyms | 1110012J17Rik, CCDC165, D130071O13, KIAA0802, microtubule crosslinking factor 1, mKIAA0802, RGD1308319, SOGA2, t8219b25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtcl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Coiled-coil region of CCDC155 or KASH
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- Domain of unknown function (DUF4482)
- PspA/IM30 family
- Protein SOGA
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Bin/Amphiphysin/Rvs domain
- chromosome segregation protein SMC, common bacterial type
- microtubule binding
- Domain of unknown function (DUF4201)
- Tropomyosin
- protein homodimerization
Pathways
Biological processes and signaling networks where the Mtcl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- breast carcinoma
- chronic obstructive pulmonary disease
- androgenic alopecia
- metastasis
- laryngeal squamous cell carcinoma
- squamous cell cancer of the larynx
- cerebellar ataxia
role in cell
- expression in
- formation
- phosphorylation in
- degradation in
- accumulation in
- binding in
- proliferation
- migration
- invasion by
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apicolateral membrane
- cytoskeleton
- midbody
- microtubule bundles
- lateral plasma membrane
- spindle pole
- spindle fibers
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtcl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of protein targeting to membrane
- microtubule bundle formation
- establishment or maintenance of epithelial cell apical/basal polarity
- regulation of autophagy
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- spindle microtubule
- apicolateral plasma membrane
- lateral plasma membrane
- extracellular space
- cytoskeleton
- cytoplasm
- spindle pole
- kinetochore
- midbody
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- RNA binding
- protein binding
- microtubule binding