Tchh Gene Summary [Mouse]
Enables protein-macromolecule adaptor activity. Acts upstream of or within intermediate filament organization. Is expressed in filiform papillae; hair inner root sheath; hair medulla; and tongue. Orthologous to human TCHH (trichohyalin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tchh |
| Official Name | trichohyalin [Source:MGI Symbol;Acc:MGI:2177944] |
| Ensembl ID | ENSMUSG00000052415 |
| Bio databases IDs | |
| Aliases | trichohyalin |
| Synonyms | AHF, AI597080, THH, THL, TRHY, Trichohyalin, UHS3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tchh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4659)
- S-100/ICaBP type calcium binding domain
- MAP7 (E-MAP-115) family
- Trichohyalin-plectin-homology domain
- protein binding activity, bridging
- calcium ion binding
- EFh
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cornified envelope
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tchh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinization
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- transition metal ion binding
- calcium ion binding