Taf4 Gene Summary [Mouse]
Enables DNA binding activity. Acts upstream of or within DNA-templated transcription and ovarian follicle development. Located in male germ cell nucleus. Is expressed in brain; spinal cord; tail; and thymus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 73. Orthologous to human TAF4 (TATA-box binding protein associated factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taf4 |
| Official Name | TATA-box binding protein associated factor 4 [Source:MGI Symbol;Acc:MGI:2152346] |
| Ensembl ID | ENSMUSG00000039117 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 4 |
| Synonyms | MRD73, TAF130, TAF2C, TAF2C1, TAF4A, TAF(II)130, TAFII-130, TAF(II)135, TAFII-135, TATA-box binding protein associated factor 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- Transcription initiation factor TFIID component TAF4 family
- transcription regulator
- nucleic acid binding
- central domain
- protein binding
- general RNA polymerase II transcription factor
- glutamine-rich domain
- sequence-specific DNA binding
- DNA binding
- histone fold domain (HFD) superfamily
- NHR1 homology to TAF
- aryl hydrocarbon receptor binding
- double-stranded DNA binding
- TAF homology
- CREB binding domain
Pathways
Biological processes and signaling networks where the Taf4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- cancer
- neurodevelopmental disorder
- hereditary disorder
- melanoma cancer
- major depression
- autosomal dominant intellectual developmental disorder type 73
- open-angle glaucoma
- benign neoplasia
- single major depressive episode
role in cell
- cell death
- apoptosis
- expression in
- proliferation
- activation in
- morphology
- induction in
- accumulation in
- growth
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- regulation of DNA repair
- transcription from RNA polymerase II promoter
- transcription initiation, DNA-dependent
- transcription initiation from RNA polymerase II promoter
- ovarian follicle development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- transcription factor TFTC complex
- cytosol
- macromolecular complex
- chromatin
- male germ cell nucleus
- MLL1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- core promoter sequence-specific DNA binding
- DNA binding
- protein binding
- aryl hydrocarbon receptor binding
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity