Get4 Gene Summary [Mouse]
Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in establishment of protein localization to membrane; maintenance of unfolded protein; and proteolysis involved in protein catabolic process. Predicted to be located in chromosome; cytoplasm; and nuclear lumen. Predicted to be part of BAT3 complex. Predicted to be active in cytosol. Is expressed in neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIy. Orthologous to human GET4 (guided entry of tail-anchored proteins factor 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Get4 |
| Official Name | golgi to ER traffic protein 4 [Source:MGI Symbol;Acc:MGI:1914854] |
| Ensembl ID | ENSMUSG00000025858 |
| Bio databases IDs | |
| Aliases | golgi to ER traffic protein 4 |
| Synonyms | 1110007L15Rik, C7orf20, CDG2Y, CEE, CGI-20, golgi to ER traffic protein 4, guided entry of tail-anchored proteins factor 4, LOC51608, RGD1311660, TRC35 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Get4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Golgi to ER traffic protein 4
- protein binding
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Get4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- tail-anchored membrane protein insertion into ER membrane
- cytoplasmic sequestering of protein
- protein insertion into ER membrane
- posttranslational protein targeting to membrane
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- BAT3 complex
- cytoplasm
- cytosol
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding