Nav2 Gene Summary [Mouse]
Enables heparin binding activity. Acts upstream of or within several processes, including cranial nerve development; sensory perception of smell; and sensory perception of sound. Located in interstitial matrix. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; limb ectoderm; and somite. Orthologous to human NAV2 (neuron navigator 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Nav2 |
| Official Name | neuron navigator 2 [Source:MGI Symbol;Acc:MGI:2183691] |
| Ensembl ID | ENSMUSG00000052512 |
| Bio databases IDs | |
| Aliases | neuron navigator 2 |
| Synonyms | 5330421F07RIK, FLJ10633, HELAD1, mKIAA3015, neuron navigator 2, POMFIL2, RAINB1, RAINB2, STEERIN2, UNC53H2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nav2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calponin homology domain
- calponin homology (CH) domain superfamily
- enzyme
- protein binding
- heparin binding
- DNA helicase
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- venous thromboembolism
- peripheral arterial disease
- vascular dementia
- headache
- hepatitis
- side effect
- acne
- attention deficit hyperactivity disorder
- acute myeloid leukemia
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nav2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- locomotory behavior
- DNA duplex unwinding
- sensory perception of smell
- nervous system development
- neurogenesis
- glossopharyngeal nerve development
- vagus nerve development
- regulation of systemic arterial blood pressure by baroreceptor feedback
- optic nerve development
Cellular Component
Where in the cell the gene product is active
- interstitial matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- heparin binding
- 3'-5' DNA helicase activity