Adarb2 Gene Summary [Mouse]
Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; integumental system; limb; and sensory organ. Orthologous to human ADARB2 (adenosine deaminase RNA specific B2 (inactive)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adarb2 |
| Official Name | adenosine deaminase, RNA-specific, B2 [Source:MGI Symbol;Acc:MGI:2151118] |
| Ensembl ID | ENSMUSG00000052551 |
| Bio databases IDs | |
| Aliases | adenosine deaminase, RNA-specific, B2 |
| Synonyms | ADAR3, adenosine deaminase RNA specific B2, adenosine deaminase, RNA-specific, B2, adenosine deaminase RNA specific B2 (inactive), LOC100130729, RED2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adarb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Double-stranded RNA binding motif
- adenosine deaminase
- double-stranded RNA binding motif (DSRM) superfamily
- double-stranded RNA binding
- enzyme
- single-stranded RNA binding
- Adenosine-deaminase (editase) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- prostate cancer
- migraine with aura
- streptococcal pharyngitis
- breast cancer
- conotruncal heart malformations
- coronary artery disease
- idiopathic scoliosis
- migraines
- side effect
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adarb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenosine to inosine editing
- RNA processing
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleolus
Molecular Function
What the gene product does at the molecular level
- RNA binding
- metal ion binding
- double-stranded RNA binding
- double-stranded RNA adenosine deaminase activity
- single-stranded RNA binding
- tRNA-specific adenosine deaminase activity
- adenosine deaminase activity