Synpo Gene Summary [Mouse]
Enables actin binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of actin filament bundle assembly; and regulation of postsynaptic cytosolic calcium ion concentration. Located in cell periphery and stress fiber. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including genitourinary system; respiratory system; sensory organ; skeleton; and tooth. Orthologous to human SYNPO (synaptopodin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Synpo |
| Official Name | synaptopodin [Source:MGI Symbol;Acc:MGI:1099446] |
| Ensembl ID | ENSMUSG00000043079 |
| Bio databases IDs | |
| Aliases | synaptopodin |
| Synonyms | 9030217H17RIK, 9130229N11, 9330140I15Rik, AW046661, KIAA1029, Synaptopodin, SYNPO1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Synpo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PPXY motif
- actin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Ullrich congenital muscular dystrophy
- nephrosis
- ulcerative colitis
role in cell
- quantity
- loss
- elongation
- shape
- expansion
- reformation
- number
- expansion in
- assembly
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- organelle
- cell periphery
- actin cytoskeleton
- Plasma Membrane
- cytosol
- dendritic spines
- spine apparatus
- synapse
- pedicels
- actin stress fibers
- tight junctions
- dendrites
- glomerular basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Synpo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- Z disc
- postsynaptic density
- tight junction
- dendritic spine
- stress fiber
- actin cytoskeleton
- cytosol
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding